Our research is in comparative and evolutionary genomics. We are interested in changes in gene regulation between species that impact the phenotype. In particular, we investigate the evolution of cis-regulatory elements, chromatin conformation, and and noncoding RNA at a genome-wide scale. We are also testing the function of specific rapidly evolving cis-regulatory regions using Massively Parallel Reporter Assays (MPRAs). We use iPSC derived cells to look at enhancer function in stem-cell derived neurons and astrocytes. Our current research addresses these essential questions as they relate to genetic and phenotypic differences between humans and non-human primates. We integrate both computational and experimental approaches to provide a more comprehensive understanding of the functional changes involved in regulatory evolution and how they contribute to phenotypic evolution.