Yubing Sun

Assistant Professor of Mechanical and Industrial Engineering

B.S., University of Science and Technology of China, 2010
Ph.D., University of Michigan, Ann Arbor, 2015

Research Interests

Our research applies and integrates fundamental engineering principles, such as manufacturing, biomechanics, materials science, and micro/nanoengineering, to understand and harness the mechanobiology of stem cells for modeling currently incurable human diseases and for applications in regenerative medicine. Current research interests include:

  • Stem cell bioengineering
  • System mechanobiology
  • Microengineering
  • Active biomaterials
  • Lab-on-chip
  • Tissue biomechanics


Koh Meng Aw Yong, Yubing Sun, Sofia D. Merajver, and Jianping Fu. Mechanotransduction-induced reversible phenotypic switching in prostate cancer cells. Biophysical Journal, vol.112, pp. 1236-1245, 2017.

Xin Cui, Weijin Guo, Yubing Sun, Baoce Sun, Shuhuan Hu, Dong Sun, Raymond HW Lam. A microfluidic device for isolation and characterization of transendothelial migrating cancer cells. Biomicrofluidics, vol. 11, 014105, 2017.

Tianfa Xie, Jamar Hawkins, Yubing Sun. Traction force measurement using deformable microposts. Methods in Molecular Biology, invited contribution, in press, 2017.

Di Chen*, Yubing Sun*, Cheri X. Deng, and Jianping Fu. Improving survival of disassociated human embryonic stem cells by mechanical stimulation using acoustic tweezing cytometry. Biophysical Journal (Biophysical Letter), vol. 108, pp. 1315-1317, 2015.

Yubing Sun, Koh Meng Aw Yong, Luis G. Villa-Diaz, Xiaoli Zhang, Weiqiang Chen, Renee Philson, Shinuo Weng, Haoxing Xu, Paul H. Krebsbach and Jianping Fu. Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells.  Nature Materials, vol. 13, pp. 599-604, 2014.

Zhenzhen Fan*, Yubing Sun*, Di Chen*, Weiqiang Chen, Cheri Deng, and Jianping Fu.  Acoustic tweezing cytometry for live-cell subcellular control of intracellular cytoskeleton contractility.  Scientific Reports, vol. 3, 2176, 2013.

Yubing Sun, Christopher S. Chen, and Jianping Fu.  Forcing stem cells to behave: A biophysical perspective of cellular microenvironment.  Annual Review of Biophysics, vol. 41, pp. 519-542, 2012.

Yubing Sun, Luis G. Villa-Diaz, Raymond Hiu-Wai Lam, Weiqiang Chen, Paul H. Krebsbach, and Jianping Fu.  Matrix mechanics regulates fate decisions of human embryonic stem cells.  PLoS ONE, vol. 7, e37178, 2012. 

Weiqiang Chen, Luis G. Villa-Diaz, Yubing Sun, Shinuo Weng, Raymond Hiu-Wai Lam, Paul H. Krebsbach, and Jianping Fu.  Nanotopography influences adhesion, spreading, and self-renewal of human embryonic stem cells.  ACS Nano, vol. 6, pp. 4094-4103, 2012.

Raymond Hiu-Wai Lam, Yubing Sun, Weiqiang Chen, and Jianping Fu.  Elastomeric microposts integrated into microfluidics for flow-mediated endothelial mechanotransduction analysis.  Lab on a Chip, vol. 12, pp. 1865-1873, 2012.