News & Announcements

Published: MCB student Yili Zhu publishes findings that microtubule-associated protein She1 is required for the maintenance of the metaphase spindle stability.

Yili Zhu research image

MCB student Yili Zhu and colleagues published a paper titled “Microtubule cross-linking activity of She1 ensures spindle stability for spindle positioning” in The Journal of Cell Biology. Using function-separating alleles, live-cell spindle assays and in vitro biochemical analyses, they show that She1 is required for the maintenance of metaphase spindle stability. Their data reveal how She1 ensures spindle integrity during spindle movement across the bud neck and suggest a potential link between regulation of spindle integrity and dynein pathway activity. Read more

Nathan Kuhlmann awarded traineeship through UMass Biotech Training Program

photo of Nathan Kuhlmann

MCB student Nathan Kuhlmann (Chien Group) received a prestigous, two-year traineeship from the NIH funded Biotech Training Program at UMass. Nathan's research is geared toward understanding more about antibiotic resistance, and utilizes a novel system that governs the cell cycle progression of Caulobacter Crescentus to uncover the structural details of adaptor hierarchy mediated protein degradation. Read more

Dom Alfandari awarded NIH grant to study the production and characterization of monoclonal antibodies to Xenopus proteins

Study Suggests Expectant Father’s Environmental Exposure Affects Reproductive Success

photo of Richard Pilsner

Early results from a larger, ongoing study led by environmental health scientist Richard Pilsner suggest that phthalate levels in expectant fathers have an effect on couples’ reproductive success via epigenetic modifications of sperm DNA. Details appear in the current issue of Human Reproduction, a monthly journal of the European Society of Human Reproduction and Embryology published by Oxford Journals. Read more

Dhankher comments on use of poplars to clean up contaminants

photo of Om Parkash Dhankher

Om Parkash Dhankher, Stockbridge School of Agriculture, was interviewed in Chemical & Engineering News about a new study from the University of Washington that looked at planting poplar trees that harbor microbes that could help clean up sites contaminated with the carcinogen trichloroethylene. He praised the method, saying, “This is a very cheap and green, clean technology.” Read more

Kulkarni Included on ‘Talented 12’ Chosen by Chemical & Engineering News

photo of Ashish Kulkarni

Ashish Kulkarni, who is joining the chemical engineering department this fall as an assistant professor, is one of the “Talented 12,” an international team of rising all-stars in chemistry, chosen by Chemical & Engineering News. Kulkarni, who is nicknamed the “Cancer Crusher” by the magazine, focuses his research on the development of pioneering, structure-activity, relationship-inspired nanomedicine for cancer therapy. Read more

Protein research by Gierasch and team has implications for disease treatment

photo of Lila Gierasch

A team led by Lila Gierasch, Biochemistry & Molecular Biology, has demystified the pathway of interdomain communication in a family of proteins known as Hsp70s—a top target of dozens of research laboratories trying to develop new anti-cancer drugs, antibiotics, and treatments for Alzheimer’s and Parkinson’s diseases. Read more

UMass Amherst Researchers Find ‘Switch’ that Turns on Immune Cells’ Tumor-Killing Ability

photo of Leonid Pobezinsky

Molecular biologists led by Leonid Pobezinsky and his wife and research collaborator Elena Pobezinskaya have published results that for the first time show how a microRNA molecule known as Lethal-7 (let-7) serves as a molecular control hub to direct the function of cytotoxic T lymphocytes by putting the brakes on their cell-killing activities. The research group led by the Pobezinskys includes his Ph.D. student and first author Alexandria Wells, UMass Amherst molecular biologist Michele Markstein, who provided the computational analysis to identify let-7 targets and how let-7 regulates the genome, and UMass Medical School immunologist Raymond Welsh, a specialist in cytotoxic CD8 T cells who provided a viral model for testing differentiation in the presence of virus. More

Madison Tyler MS Thesis Defense

Monday, August 28, 2017
10:00 am
Hasbrouck, Room 409
Thesis Title:  Regulation of Katanin Activity on Microtubules
Advisor:  Jenny Ross

Vachet Receives Grant to Study, Prevent Protein Aggregation

photo of Richard Vachet

Richard Vachet, chemistry, received a four-year, $1.2 million grant from the National Institutes of Health to continue his group’s study of the aggregation by βeta-2-microglobulin (β2m), the protein that forms amyloid fibril deposits in the joints of patients with kidney disease who are undergoing dialysis. Read more

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