Jun Ding, Assistant Professor of Neurosurgery, Stanford University School of Medicine
Ph.D. in Neuroscience, Department of Physiology, Northwestern University
M.S. in Physiology, Shanghai Institute of Physiology, Chinese Academy of Sciences, China
B.S. in Biology, Department of Biology, East China Normal University, Shanghai, China
The interplay between motor cortex, sensory cortex, thalamus and basal ganglia is essential for neural computations involved in generating voluntary movements. Our goal is to dissect the functional organization of motor circuits, particularly cortico-thalamo-basal ganglia networks, using electrophysiology, 2-photon microscopy, optogenetics, and genetic tools.
The long-term scientific goal of the Ding Lab is to construct functional circuit diagrams and establish causal relationships between activity in specific groups of neurons, circuit function, animal motor behavior and motor learing, and, thereby, to decipher how the basal ganglia process information and guide motor behavior. We will achieve this by investigating the synaptic organization and function that involve the cortex, thalamus and basal ganglia at the molecular, cellular and circuit level.
Jones G. Parker, Jesse D. Marshall, Biafra Ahanonu, Yu-Wei Wu, Tony Hyun Kim, Benjamin F. Grewe, Yanping Zhang, Jin Zhong Li, Jun B. Ding, Michael D. Ehlers & Mark J. Schnitzer. Diametric neural ensemble dynamics in parkinsonian and dyskinetic states. Nature. (in press).
Konstantin Kaganovsky and Ding JB*. The Locomotion Tug-of-War: Cholinergic and Dopaminergic Interactions Outside the Striatum. Neuron 2017, December 20; 96. doi:10.1016/j.neuron.2017.12.014
Wu YW and Ding JB*. A Cell-type-specific jolt for motor disorders. Nat Neurosci. 2017 May; 20, 763-765 (2017) doi:10.1038/nn.4565.
Du K, Wu YW, Lindroos R, Liu Y, Rózsa B, Katona G, Ding JB*, Kotaleski JH*. Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. Proc Natl Acad Sci U S A. 2017 Aug 21. pii: 201704893. doi: 10.1073/pnas.1704893114. (* Corresponding author)
Chen CC, Lu J, Yang R, Ding JB, Zuo Y. Selective activation of parvalbumin interneurons prevents stress-induced synapse loss and perceptual defects. Mol Psychiatry. 2017 Aug 1. doi: 10.1038/mp.2017.159. [Epub ahead of print]
Xu TH, Wang SF, Lalchandani RR, and Ding JB. Motor learning in animal models of Parkinson's Disease: Aberrant synaptic plasticity in the motor cortex. Mov Disord. 2017 Mar 25. doi: 10.1002/mds.26938.
Luo SX, Timbang L, Kim JI, Shang Y, Sandoval K, Tang AA, Whistler JL, Ding JB, Huang EJ. TGF-β Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning. Cell Reports. 2016 Dec 20;17(12):3233-3245. doi: 10.1016/j.celrep.2016.11.068.
Xu T, Wang S, Lalchandani RR, Ding JB. Motor learning in animal models of Parkinson's Disease: Aberrant synaptic plasticity in the motor cortex. Mov Disord. 2017 Mar 25. doi: 10.1002/mds.26938.
Kim J-I, Ganesan S, Luo SX, Wu Y-W, Park E, Huang EJ, Chen L, and Ding JB. Aldehyde Dehydrogenase 1a1 Mediates a GABA Synthesis Pathway in Midbrain Dopaminergic Neurons. Science, 2015 Oct 2;350(6256):102-6. doi: 10.1126/science.aac4690.
Guo L, Xiong H, Kim J-I, Wu Y-W, Lalchandani RR, Cui Y, Shu Y, Xu T and Ding JB. Dynamic re-wiring of neural circuits in the motor cortex in mouse models of Parkinson’s disease. Nat Neurosci, 2015 Sep;18(9):1299-309. doi: 10.1038/nn.4082. Epub 2015 Aug 3. (Previewed by: Calabresi and Di Filippo, Nature Neuroscience 18, 1196–1198 (2015) doi:10.1038/nn.4092)
Wu YW, Kim JI, Tawfik VL, Lalchandani, RR, Scherrer G and Ding JB. Input- and cell type-specific endocannabinoid-dependent LTD in the striatum. Cell Reports. 2015 Jan 6;10(1):75-87. doi: 10.1016/j.celrep.2014.12.005. Epub 2014 Dec 24.