Mandy Muller
Assistant Professor of Microbiology
Ph.D.: Virology, Pasteur Institute, 2013
Research Interests
Viruses reshape the intracellular environment during infection, both to hijack processes necessary for viral amplification and to subvert antiviral defenses. Because of size constraints and competition with their hosts for resources, they have developed ingenious ways to benefit from the host gene expression machinery. As such, viruses are excellent tool to understand cell biology. Herpesviruses are a particularly good example of such successful balance as herpesvirus infections are life-long and cannot be cleared by the host. We focus on the Gamma-herpesviruses and in particular, KSHV (Kaposi Sarcoma Associated Herpesvirus). We are especially interested in understanding how these viruses induce major changes in mRNA stability during infection, as well as how the host cell reacts to the viral takeover.
Publications
Rodriguez W, Srivastav A, Muller M. C19ORF66 broadly escapes viral-induced endonuclease cleavage and restricts Kaposi Sarcoma Associated Herpesvirus (KSHV). J Virol p. JVI.00373-19, 2019
Muller M, Glaunsinger BA. 2017. Nuclease escape elements protect messenger RNA against cleavage by multiple viral endonucleases. PLOS Pathogens. 13:e1006593.
Muller M, Hutin S, Marigold O, Li KH, Burlingame A, Glaunsinger BA. 2015. A Ribonucleoprotein Complex Protects the Interleukin-6 mRNA from Degradation by Distinct Herpesviral Endonucleases. PLOS Pathogens. 11:e1004899.
Muller M, Demeret C. 2014. CCHCR1 Interacts Specifically with the E2 Protein of Human Papillomavirus Type 16 on a Surface Overlapping BRD4 Binding. PLoS ONE. 9:e92581.
Muller M, Cassonnet P, Favre M, Jacob Y, Demeret C. 2013. A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions. Journal of Visualized Experiments.
Muller M, Demeret C. 2012. The {HPV} E2-Host Protein-Protein Interactions: A Complex Hijacking of the Cellular Network. The Open Virology Journal. 6:173–189.
Muller M, Jacob Y, Jones L, Weiss A, Brino L, Chantier T, Lotteau V, Favre M, Demeret C. 2012. Large Scale Genotype Comparison of Human Papillomavirus E2-Host Interaction Networks Provides New Insights for E2 Molecular Functions. {PLoS} Pathogens. 8:e1002761.
Neveu G, Cassonnet P, Vidalain P-O, Rolloy C, Mendoza J, Jones L, Tangy F, Muller M, Demeret C, Tafforeau L et al.. 2012. Comparative analysis of virus–host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase. Methods. 58:349–359.
Cassonnet P, Rolloy C, Neveu G, Vidalain P-O, Chantier T, Pellet J, Jones L, Muller M, Demeret C, Gaud G et al.. 2011. Benchmarking a luciferase complementation assay for detecting protein complexes. Nature Methods. 8:990–992.