Associate Professor of Food Science, University of Massachusetts
Ph.D.: University of Wisconsin-Madison Postdoctoral Training:University of California-Davis
The processes of inflammation and angiogenesis in the tumor microenvironment are increasingly implicated in tumorigenesis. While most efforts to study inflammation and angiogenesis have focused on proteinaceous mediators, the roles of lipid mediators have received little attention. Our research focuses on actions and mechanisms of ω-3 polyunsaturated fatty acids (PUFAs)-derived signaling lipids on angiogenesis, inflammation and tumorigenesis. These research projects will elucidate the molecular mechanisms by which ω-3 PUFAs reduce risks of angiogenic diseases and cancers, leading to development of better nutritional paradigms and human trials to clarify the nutritional effects of ω-3 PUFAs. In addition, the identified endogenous bioactive lipid mediators could serve as biotemplates to design more potent and safer therapeutics. We use a combination of LC-MS/MS-based lipidomics, organic synthesis, primary cell cultures and animal models to investigate the effects and mechanisms of lipid metabolism on human diseases.