News & Announcements

Lea Doerries MasterThesis defense

05/15/2024 - 5:30pm

Title: "

ADDING PIECES TO THE PUZZLE OF Hsc70’S SUBSTRATE SELECTIVITY:

A COMPARISON OF SUBSTRATE BINDING SELECTIVITY IN DnaK AND Hsc70".

Advisor: Lila Gierasch

May 15 at 10:00 am in LSL N410

CONGRATULATIONS to our second year cohort who has passed their ORP examination!!

05/15/2024 - 5:15pm

MS Thesis Defense - Max Campbell

04/08/2024 - 9:45am

Advisor: Peter Chien

 Monday April 8 

4pm in LSL N210

Jessica McGory Dissertation Defense

04/05/2024 - 11:00am

Title: "The role of intrinsically disordered proteins in the regulation of chromosome segregation"

Advisor: Thomas Maresca

Thursday April 11, 2024
1:00 PM
LGRT 1681

Zoom link: https://umass-amherst.zoom.us/j/97898155068

Successful Biotech Training Program Retreat in Boston

03/27/2024 - 1:45pm

The Biotech Training Program (BTP) had an excellent time at our 3-day retreat in the Biotech Hub in Boston. We visited Ginko Bioworks, Dewpoint Therapeutics and experienced an excellent tour of Vertex Cell Therapies group with MCB alumni Brad Pearse!

 

Researchers at UMASS Amherst Shed Light on How Tumor Cells Outwit the Body's Immune System

01/19/2024 - 1:00pm

In a first-of-its-kind research breakthrough, a team of scientists at the University of Massachusetts Amherst has analyzed and described what they call the “mosquito effect,” which sheds light on how certain pathogens, such as cancerous tumor cells, can outwit the body’s immune system.

Just as mosquitoes ingest their host’s blood, the immune system’s T cells incorporate cytoplasmic material from tumors into their own cytoplasm. While it has long been known that many kinds of cells can transfer cellular material from one to another, the transfer of the cytoplasm has never been observed in T cells. Subsequent single-cell RNA (scRNA) sequencing shows that cytoplasm from tumor cells alters the machinery responsible for protein coding in the host T cell. The research, reported recently in the journal Frontiers in Immunology, is a major step forward in understanding how tumors can successfully evade the immune system, and thus a step toward more effective treatments.

To make the discovery, Pobezinsky and his team, including first author Kaito Hioki, graduate student in the MCB program at UMass Amherst, and Elena Pobezinskaya, research assistant professor also in veterinary and animal sciences at UMass and co-senior author of the paper, engineered tumor cells to produce an ultrabright fluorescent protein called ZsGreen. They then introduced the green-glowing tumor cells into a mouse model. After eight days, the model’s tumor-infiltrating immune cells were gathered and analyzed using state-of-the-art equipment in the Flow Cytometry lab at UMass Amherst’s Institute for Applied Life Sciences. Read more

UMASS Amherst Researchers Crack the Cellular Code on Protein Folding, Opening New Therapeutic Avenues for Many Diseases

01/19/2024 - 12:45pm

While we often think of diseases as caused by foreign bodies—bacteria or viruses—there are hundreds of diseases affecting humans that result from errors in cellular production of its proteins. A team of researchers led by the University of Massachusetts Amherst recently leveraged the power of cutting-edge technology, including an innovative technique called glycoproteomics, to unlock the carbohydrate-based code that governs how certain classes of proteins form themselves into the complex shapes necessary to keep us healthy.

The research, published in the journal Molecular Cell, explores members of a family of proteins called serpins, which are implicated in a number of diseases. The research is the first to investigate how the location and composition of carbohydrates attached to the serpins ensure that they fold correctly. Serious diseases—ranging from emphysema and cystic fibrosis to Alzheimer’s disease—can result when the cellular oversight of protein folding goes awry. Identifying the glyco-code responsible for high-fidelity folding and quality control could be a promising way for drug therapies to target many diseases.

The discovery of the carbohydrate-based chaperone system in the ER was due to the pioneering work that Daniel Hebert, professor of biochemistry and molecular biology at UMass Amherst and one of the paper’s senior authors, initiated as a postdoctoral fellow in the 1990s. “The tools we have now, including glycoproteomics and mass spectrometry at UMass Amherst’s Institute for Applied Life Sciences, are allowing us to answer questions that have remained open for over 25 years,” says Hebert. “The lead author of this new paper, Kevin Guay, is doing things I could only dream of when I first started.” Read more

Jun-Goo Kwak PhD Dissertation Defense

 

01/09/2024 - 6:45pm

Title: "“IN VITRO BONE MARROW MODELS TO INTERROGATE THE IMPACTS OF
SEQUESTRATION AND SECRETION BY BONE MARROW ADIPOCYTES”

Advisor: Jungwoo Lee

LSL N410 

January 11th at 1:00 pm

Navya Sebastian Masters Thesis Defense

12/19/2023 - 11:30pm

Title:"Understanding the Functional Impact of Disease-Associated Phosphorylation Sites on the Neurodegenerative Protein Tau"

Advisor: Jennifer Rauch

December 19th at 12:30pm in LSL N410

Parag Juvale PhD Thesis Defense 

12/19/2023 - 11:15pm

Title: "Postsynaptic Changes in Inhibitory Signaling are not Necessary for Experience-Dependent Maintenance of the Visual System"

Advisor: Sarah Pallas

December 20, at 12 pm

Location: Room 222, Morrill

 

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