News & Announcements

IDGP Diversity, Equity and Inclusion Statement

The Interdepartmental Graduate Programs in Life Sciences (IDGPs) believe that a diverse, equitable and inclusive environment is critical to all that we do.  We recognize that systemic racism exists in our society and we pledge to educate ourselves so that we can change our ingrained habits and beliefs. We are committed to make our programs accessible to all and to increase the success of all our members. We dedicate our time, effort and financial resources to these activities. We work with Institutional leaders, faculty, staff and students to achieve these goals. We are providing this pdf link so that you are able to view a working document of our activities. 

We are proud of our amazing students and post docs who have worked tirelessly for the betterment of our community. Our students have fostered a tight-knit, progressive community and their recent efforts have resulted in this petition for systematic change.  We stand with them in recognizing that change is required in order to make progress toward a more equitable, just, diverse and inclusive environment. 

The University has established an Office of Diversity, Equity and Inclusion and their website provides links to many resources. We encourage you to make use of these tools, including links to videos, books and podcasts as well as programing, as we embark together on our journey to improve our community for all our members.  

Juan Guillermo (Guillo) Cadena Memorial Fund

photo of Dr. Juan Guillermo (Guillo) Cadena

Dr. Juan Guillermo (Guillo) Cadena

Guillo was born in Chicago, IL. on November 22, 1969, and grew up in Tampa, Florida. Guillo was a graduate of Jesuit High School in Tampa where he excelled in athletics and was a member of the state champion soccer team. He moved to New England in the mid-1990s and received his undergraduate degree from the University of Massachusetts Amherst in 2000. After a brief return to Florida, Guillo moved back to Amherst in 2002 to join the Molecular and Cellular Biology (MCB) graduate program as a Ph.D. candidate. Guillo received his Ph.D. in 2009 under the mentorship of Dr. Larry Schwartz. Dr. Cadena’s research focused on understanding why a certain population of cells called dopaminergic neurons are uniquely vulnerable to degeneration in individuals with autosomal juvenile parkinsonism (ARJP).

Guillo was extremely dedicated to his research and had always credited the successful completion of his Ph.D. to the strong support of his advisor Dr. Schwartz, as well as many distinguished faculty members in the MCB program who guided him throughout the process. Guillo also conducted research at the Pioneer Valley Life Sciences Institute in Springfield, MA.

In his teenage years, Guillo was diagnosed with aplastic anemia and sought a suitable bone marrow donor for nearly 30 years. In 2010, Guillo was diagnosed with metastatic cancer and within a few months had succumbed to complications from chemotherapy treatment. At the time of his passing in July, 2010 Guillo was survived by his wife, 2-year old twins (Amaya and Gabriel), parents, siblings, and many close friends.

The Cadena Travel and Training Fund

The Cadena Travel and Training Fund was established in 2020, 10 years after Guillo’s passing. In memory of his dedication to science and teaching, Guillo’s close friends Nasser and Susanne Rusan, with help and support from Guillo’s family, believed it was only fitting to keep Guillo’s memory alive by giving back to the MCB program, a program that Guillo deeply cherished. Read more

Sela Moderates Briefing on Nutrition in the Human Microbiome for Congressional Staffers

photo of David Sela

On Wednesday, July 28, a briefing was held for congressional staffers on the central role of nutrition to the human microbiome, which is the collection of beneficial microbes that are contained within the human body. This briefing was jointly organized by The American Society for Microbiology and The American Society for Nutrition and moderated by University of Massachusetts Amherst food science faculty member, David A. Sela. This briefing is part of a larger initiative led by the American Society for Microbiology to advocate for additional resources to study the human microbiome.  

The briefing drew over 450 attendees with representatives from at least six congressional offices. The remainder of the participants were from the executive branch including HHS (NIH/FDA) and USDA, academic and industry scientists and practitioners who were obtaining continuing professional education credits. 

A recording of the briefing could be accessed at https://nutrition.org/asm-joint-webinar/ Read more

UMass ADVANCE Announces 2021-22 ADVANCE Faculty Fellows

UMass Advance image

UMass ADVANCE is pleased to announce the 2021-22 cohort of ADVANCE Faculty Fellows. The 46 selected faculty members, each representing different units, will partner with UMass ADVANCE to promote gender and racial equity for faculty at UMass. Through a combination of research, programming, and practices, UMass ADVANCE seeks to understand systemic and intersectional inequalities at UMass and to lay the groundwork for a fairer, more equitable, diverse and inclusive campus. 

Faculty Fellows provide recommendations and feedback to the team about ADVANCE programming and liaise with their departments to promote the ADVANCE program. They also inform ADVANCE about successful equity and inclusion initiatives in their units.

Each year ADVANCE announces a theme related to our focus on collaboration and equity. UMass ADVANCE’s theme for the upcoming program year is “Shared Decision-Making and Equity in Faculty Governance.”

Congratulations to the MCB faculty:  Ashish Kulkarni (chemical engineering), ChangHui Pak (biochemistry and molecular biology), Patrick Flaherty (mathematics and statistics), and to all of the ADVANCE Faculty Fellows! Read more

Emeritus Professor Edward Westhead Dies at Age 90

photo of Edward Westhead

Distinguished biochemist Edward W. Westhead, emeritus professor of the biochemistry and molecular biology department at UMass Amherst, succumbed to cancer on June 1, 2021 at the age of 90. Edward Westhead formed the UMass Amherst biochemistry department and also was the first director of the molecular and cellular biology Ph.D. program. 

Westhead had a passion for learning and broad interests. After receiving his B.S. and M.S. degrees in chemistry from Haverford College, and his Ph.D. in polymer science from the Polytechnic Institute of Brooklyn, he continued on to do postdoctoral research in protein biochemistry and enzyme catalysis at the University of Uppsala and University of Minnesota, respectively. He then established his own laboratory at Dartmouth Medical School in 1960.

UMass Amherst recruited Westhead in 1966 to form a new department of biochemistry. He later became the first director of the UMass Amherst molecular and cellular biology PhD program in 1988. Over the decades, he also held visiting professorship positions at various institutions, including California Institute of Technology, Oxford University, University of Innsbruck and the University of Milan. Read more

Kyle Mahan MS Thesis Defense

Monday, August 16, 2021
12:00 PM
LGRT A301/Zoom hybrid
Zoom link:  Please contact mcb@mcb.umass.edu(link sends e-mail) to be included on the email list for this announcement
Dissertation Title:  Development of a site-specific labeling assay to study the Pseudomonas aeruginosa Type III secretion translocon in native membranes
Advisor:  Alejandro Heuck

Alam García-Heredia PhD Dissertation Defense

photo of Alam Garcia-Heredia

Thursday, August 19, 2021
10:00 AM
Morrill 2, Room 222/Zoom hybrid
Zoom link:  Please contact mcb@mcb.umass.edu to be included on the email list for this announcement
Dissertation Title:  Synthesis and targeting of the bacterial cell wall
Advisor:  Sloan Siegrist

Ana Torres-Ocampo PhD Dissertation Defense

photo of Ana P. Torres-Ocampo

Thursday, August 19, 2021
2:00 PM
ILC N101/Zoom hybrid
Zoom link:  Please contact mcb@mcb.umass.edu to be included on the email list for this announcement
Dissertation Title:  Understanding how CaMKII holoenzyme dynamics facilitates activation-triggered subunit exchange
Advisor:  Meg Stratton

Decrease in Neurotransmitter Release Found in Neurons Derived from People with Schizophrenia and a Rare Genetic Mutation

A scientific team has shown that the release of neurotransmitters in the brain is impaired in patients with schizophrenia who have a rare, single-gene mutation known to predispose people to a range of neurodevelopmental disorders.

Significantly, the results from the research with human-derived neurons validated previous and new experiments that found the same major decrease in neurotransmitter release and synaptic signaling in genetically engineered human neurons with the same genetic variant – the deletion of neurexin 1 (NRXN1). NRXN1 is a protein-coding gene at the synapse, a cellular junction that connects two nerve cells to communicate efficiently.

Both the research with human-derived and engineered human neurons also found an increase in the levels of CASK, an NRXN1-binding protein, which were associated with changes in gene expression.

“Losing one copy of this neurexin 1 gene somehow contributes to the etiology or the disease mechanism in these schizophrenia patients,” says molecular neuroscientist ChangHui Pak, assistant professor of biochemistry and molecular biology at the University of Massachusetts Amherst and lead author of the research published in the Proceedings of the National Academy of Sciences. “It causes a deficit in neural communication.” Read more

Researchers Downes, Pak Win 2021 Armstrong Fund for Science Award at UMass Amherst

The Armstrong Fund for Science at UMass Amherst has announced that its 2021 award will go to Gerald Downes, biology, and ChangHui Pak, biochemistry and molecular biology, for their collaborative project that seeks to better understand how mutation of a gene known as TBCK disrupts brain development. Mutations in the TBCK gene cause a rare, severe, poorly understood neurological disease called TBCK Syndrome. Downes and Pak will receive a two-year, $40,000 grant to support preliminary investigations in preparation for a full-blown research effort.

Benefactors John and Elizabeth Armstrong established their Fund for Science in 2006 to identify and support promising research directions that do not yet have enough data available for the principals to apply to standard funding channels.

Downes and Pak plan a two-pronged approach: Downes, who has worked for years with zebrafish, has already engineered a variety of the fish with TBCK Syndrome. His lab will study how TBCK effects brain development and interacts with the mTOR pathway. Pak is an expert in the use of human-induced pluripotent stem cells. “We can grow these stem cells, reprogram and rewind them back to the embryonic stage of brain development,” she says. “Then we can engineer specific mutations, like TCBK, grow the stem cells into neurons, and run a variety of studies to compare and contrast the healthy cells with the abnormal ones.”

“We’ll be working in parallel,” says Downes, “learning from the insights provided by each model.”

Once they have preliminary results in hand, Downes and Pak will be well-positioned to seek major, multi-year support for a more comprehensive study. “The Armstrong Fund is letting us jump-start our project,” says Pak. “Without this support, it would be difficult to get our work off the ground.” Read more

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