Michele Markstein

Assistant Professor, Department of Biology

Research Interests

Regulation of gene expression, Genome architecture, Epigenetics of intestinal and neural stem cells. 

We are interested in understanding fundamental mechanisms that coordinate and compartmentalize the transcription of genes as a function of their positions in the genome. We have found that the effects of genome position vary across cell types indicating that genome position effects are plastic. To study the mechanisms and consequences of genome plasticity we use the fruit fly Drosophila melanogaster where we develop transgenic probes, disease models, chemical assays and bioinformatics tools to study position effects across cells in a multicellular animal.